Ihtiyar, EnverAlgin, CemHaciolu, AlperIsiksoy, Serap2006-01-292009-05-292006-01-292009-05-292006-01-29Ihtiyar E, Algin C, Haciolu A, Isiksoy S. Fatal isoflurane hepatotoxicity without re-exposure. Indian Journal of Gastroenterology. 2006 Jan-Feb; 25(1): 41-2http://imsear.searo.who.int/handle/123456789/65053Isoflurane is less hepatotoxic than its predecessors, halothane and enflurane. We present a 68-year-old man who developed fulminant and fatal hepatic necrosis two days after open cholecystectomy done under isoflurane anesthesia. Laboratory findings included grossly elevated transaminases and bilirubin and prolonged prothrombin time. Serological studies were negative for viral hepatitis. Postmortem examination demonstrated centrilobular necrosis of liver.engAgedAnesthesia, General --adverse effectsAnesthetics, Inhalation --adverse effectsCholecystectomyCholecystitis --surgeryFatal OutcomeHumansIsoflurane --adverse effectsLiver Diseases --chemically inducedMaleNecrosisCase Reports