Bal, Munita MeenuDas Radotra, BishanSrinivasan, RadhikaSharma, Suresh C2006-10-232009-05-292006-10-232009-05-292006-10-23Bal MM, Das Radotra B, Srinivasan R, Sharma SC. Does c-erbB-2 expression have a role in medulloblastoma prognosis? Indian Journal of Pathology & Microbiology. 2006 Oct; 49(4): 535-9http://imsear.searo.who.int/handle/123456789/75823The prognosis of patients with medulloblastoma has remained same for the last two decades. This study evaluated the role of c-erbB-2 expression in medulloblastoma as a prognostic marker. Fifty cases of medulloblastomas were investigated for the expression of c-erbB-2 protein using immunohistochemistry. The expression of c-erbB-2 was correlated with age, histology and disease-free survival (DFS). Thirty-five (70%) tumors were c-erbB-2 positive. Immunoreactivity for c-erbB-2 receptor was observed as mixed cytoplasmic and membrane positivity of tumour cells. The mean DFS in c-erbB-2 positive cases was 19.81 months compared to 48.33 months in c-erbB-2 negative cases. c-erbB-2 positivity was found to be an independent predictor of poor outcome in medulloblastoma (p value < 0.05). No correlation of c-erbB-2 expression was observed with the age of patient and the histological type of tumour. Additionally, c-erbB-4 expression was also evaluated in these tumours. Thirty-three cases showed co-expression of c-erbB-2 and c-erbB-4 proteins. However, c-erbB-4 expression alone was not associated with poor outcome, whereas its co-expression with c-erbB-2 was associated with shorter DFS (p < 0.05).engAdolescentAdultChildChild, PreschoolDisease-Free SurvivalFemaleHumansImmunohistochemistryInfantMaleMedulloblastoma --diagnosisMiddle AgedPrognosisReceptor, Epidermal Growth Factor --metabolismReceptor, erbB-2 --metabolismJournal Article