Kedar, VPurohit, HFreeze, EHempel, F2009-05-282009-05-281997-02-01Kedar V, Purohit H, Freeze E, Hempel F. Cerebellar granule cell membranes and glutamate mediates transactivation of glutamine synthetase promoter. Indian Journal of Experimental Biology. 1997 Feb; 35(2): 123-7http://imsear.searo.who.int/handle/123456789/61700Potential region of glutamine synthetase promoter driving astrocyte-specific transactivation, mediated by cerebellar granule cell membrane and glutamate has been identified by deletion analysis of promoter and transient transfection. The promoter region from -420 to -765 was found to be potentially important for this transactivation. These results provided further evidence for importance of neuronal-glial and glutamate-glial interactions in regulation of glial gene expression.engAstrocytes --cytologyCerebellum --cytologyCytoplasmic Granules --physiologyGlutamate-Ammonia Ligase --geneticsGlutamic Acid --physiologyHumansIntracellular Membranes --physiologyMutagenesis, Site-DirectedNeurons --cytologyPromoter Regions, GeneticTranscriptional ActivationTumor Cells, CulturedJournal Article