Kumar, AkashBaghmar, SaphaltaMehta, PrashantTiwari, PriyaKumar, LalitBakhshi, SameerAgarwal, AmitGupta, IshaanTrikha, AnjanBhatnagar, SushmaGogia, AjayMalik, Prabhat SinghSahoo, Ranjit KumarRastogi, SameerPramanik, RajaBatra, AtulPushpam, DeepamSharma, Chitresh KSharma, VinodKataria, BabitaGoyal, KapilSamaga, ShreyasBothra, Sneha JSharma, Atul2023-08-192023-08-192022-06Kumar Akash, Baghmar Saphalta, Mehta Prashant, Tiwari Priya, Kumar Lalit, Bakhshi Sameer, Agarwal Amit, Gupta Ishaan, Trikha Anjan, Bhatnagar Sushma, Gogia Ajay, Malik Prabhat Singh, Sahoo Ranjit Kumar, Rastogi Sameer, Pramanik Raja, Batra Atul, Pushpam Deepam, Sharma Chitresh K, Sharma Vinod, Kataria Babita, Goyal Kapil, Samaga Shreyas, Bothra Sneha J, Sharma Atul. Characteristics & outcomes of cancer patients with COVID-19: A multicentre retrospective study from India. Indian Journal of Medical Research. 2022 Jun; 155(5-6): 546–5530971-5916http://imsear.searo.who.int/handle/123456789/223627Background & objectives: High mortality has been observed in the cancer population affected with COVID-19 during this pandemic. We undertook this study to determine the characteristics and outcomes of cancer patients with COVID-19 and assessed the factors predicting outcome. Methods: Patients of all age groups with a proven history of malignancy and a recent diagnosis of SARS-CoV-2 infection based on nasal/nasopharyngeal reverse transcriptase (RT)-PCR tests were included. Demographic, clinical and laboratory variables were compared between survivors and non-survivors groups, with respect to observed mortality. Results: Between May 11 and August 10, 2020, 134 patients were included from the three centres and observed mortality was 17.1 per cent. The median age was 53 yr (interquartile range 39-61 yr) and thirty four patients (25%) were asymptomatic. Solid tumours accounted for 69.1 per cent and breast cancer was the most common tumour type (20%). One hundred and five patients (70.5%) had received chemotherapy within the past four weeks and 25 patients (19.3%) had neutropenia at presentation. On multivariate analysis, age [odds ratio (OR) 7.99 (95% confidence interval [CI] 1.18-54.00); P=0.033], haemoglobin [OR 6.28 (95% CI 1.07-37.04); P=0.042] neutrophil–lymphocyte ratio [OR 12.02 (95% CI 2.08-69.51); P=0.005] and baseline serum albumin [OR 18.52 (95% CI 2.80-122.27); P=0.002], were associated with higher mortality. Recent chemotherapy, haematological tumours type and baseline neutropenia did not affect the outcome. Interpretation & conclusions: Higher mortality in moderate and severe infections was associated with baseline organ dysfunction and elderly age. Significant proportion of patients were asymptomatic and might remain undetectedCancerCOVID-19infectionmortalityoutcomeJournal ArticleIndiaDepartments ofMedical OncologySurgical Oncology, National Cancer Institute, Departments ofMedical OncologyOnco-Anaesthesia & Palliative Medicine, Dr B.R. Ambedkar Institute Rotary Cancer HospitalDepartment of Anaesthesiology, Pain Medicine & Critical Care, All India Institute of Medical SciencesDepartment of Medical Oncology, BL Kapur HospitalDepartment of Biochemical Engineering & Biotechnology, Institute of Technology, New DelhiDepartment of Medical Oncology/Hematology/BMT, Asian Institute of Medical SciencesDepartment of Medical Oncology, Artemis Hospital, Gurugram, Haryana, India