Saffoon, NadiaUddin, RiazHuda, Naz HasanSutradhar, Kumar Bishwajit2014-05-152014-05-152011-09Saffoon Nadia, Uddin Riaz, Huda Naz Hasan, Sutradhar Kumar Bishwajit. Enhancement of oral bioavailability and solid dispersion: A review. Journal of Applied Pharmaceutical Science. 2011 Sept; 1(7): 13-20.http://imsear.searo.who.int/handle/123456789/150890Improving oral bioavailability of drugs those given as solid dosage forms remains a challenge for the formulation scientists due to solubility problems. Most of the newly invented chemical entities are poorly water soluble. As a result formulating them as oral solid dosage forms is a hurdle to the specialists. Many techniques have been exercised to improve oral bioavailability of drugs. Among several methods, solid dispersion has attracted attention of the researchers for previous 50 years. Different formulation strategies have been taken to prepare solid dispersions. It is evident that solid dispersions improve solubility of drug particles thus enhancing dissolution characteristics of drugs they increase the oral bioavailability. This review paper will focus on different aspects of solid dispersion preparation; their advantages, major challenges and preparation methods.enBioavailabilitySolubilityHot melt extrusionCarrierBiopharmaceutical classificationHot-spin-meltingArticle