Sethi, O PIsmail, A MBhavsar, G CTrivedi, B MGulati, O D1987-04-012009-06-011987-04-012009-06-011987-04-01Sethi OP, Ismail AM, Bhavsar GC, Trivedi BM, Gulati OD. Action of some amides of substituted ethylenediamines on central nervous system. Indian Journal of Physiology and Pharmacology. 1987 Apr-Jun; 31(2): 125-9http://imsear.searo.who.int/handle/123456789/108515Five of the substituted ethylenediamine amides (LMG I to V) were tested for various CNS attributes and for acute toxicity (24 hr mortality). All compounds were potent analgesics in various animal tests, LMG V being most potent. All reduced spontaneous activity of mice and potentiated ether anaesthesia. However, CAR was not altered and anti-MES were not pronounced in rats. Compounds appear to have a wide safety margin considering ED50 and LD50 in mice.engAmides --pharmacologyAnalgesics --pharmacologyAnimalsCentral Nervous System --drug effectsEthylenediamines --pharmacologyFemaleLethal Dose 50MaleMiceMotor Activity --drug effectsRatsReflex --drug effectsJournal Article