Dhakad, Gajendra SinghKunjunni, RemeshMishra, Arun2023-08-092023-08-092023-03Dhakad Gajendra Singh, Kunjunni Remesh, Mishra Arun. HYPOVITAMINOSIS D EXACERBATES TYPE 2 DIABETIC COMORBIDITIES. Indian Journal Of Applied Research. 2023 Mar; 13(3): 8-112249-555Xhttp://imsear.searo.who.int/handle/123456789/221372Vitamin D deficiency is one of the prominent nutritional deficiencies in India that needs special attention. The effects of hypovitaminosis D on skeletal and cardiovascular functions are well known. However, its effect on metabolic disorders like type 2 diabetes mellitus (T2DM) is still left unexplored. In the present study, our primary aim is to find out the potential effect of hypovitaminosis D in T2DM patients. The study was conducted on 250 T2DM patients mainly from Madhya Pradesh, India. Among them, 125 had hypovitaminosis D (case group) and were compared against the control group of 125 patients with normal serum vitamin D. We were mainly investigating the major T2DM-related complications including chronic kidney disease (CKD), coronary heart disease (CHD and recurrent infections. Major organ functions including liver, kidney, and cardiac functions were affected by hypovitaminosis D in T2DM patients when compared to control counterparts. We also noticed an association between hypovitaminosis D and the exacerbation of T2DM comorbidities. Our findings show the importance of maintaining normal serum vitamin D levels in T2DM patients to avoid further complications.Hypovitaminosis DT2DMCKDCHDChronic infectionsJournal ArticleIndiaDepartment of Biochemistry, Index Medical College, Indore, Madhya PradeshDepartment of Biochemistry, Government Medical College, Kota, RajasthanDepartment of Biochemistry, Index Medical College, Indore, Madhya Pradesh.*Corresponding Author