Iqbal, Mohammed JafarIslam, Mirza Md. ZiaulIslam, AtiqulSen, Tanusree2025-08-132025-08-132025-02Iqbal Mohammed Jafar, Islam Mirza Md. Ziaul, Islam Atiqul, Sen Tanusree . Renal development and functional outcomes: A comparative study of term low birth weight and normal birth weight infants. Annals of International Medical and Dental Research. 2025 Feb; 11(1): 21-272395-28222395-2814https://imsear.searo.who.int/handle/123456789/250008Introduction: One of the biggest issues facing emerging nations is low birth weight (LBW). In our situation, the term LBW may be caused by maternal malnourishment, inadequate prenatal care, low socioeconomic position, repeated pregnancies with close spacing, and a lack of health knowledge. The proper renal development of LBW newborns resulting from intrauterine growth retardation is negatively impacted. Renal functional maturity can be predicted by examining the link between renal function and volume. The aim of this study was to compare the renal volume and functional status in the term LBW versus term normal birth weight (NBW) babies at 1 year. Materials and Methods: This case–control study was conducted at the Department of Pediatric Infectious Disease and Community Pediatrics at Bangladesh Shishu Hospital and Institute, Dhaka, from June 2009 to May 2010. Patients were selected according to inclusion and exclusion criteria. 100 children were recruited in this study at 1 year of age from that hospital. Among them 50 were born at term with NBW and the rest 50 were born at term with LBW. Data were collected by developing a structured questionnaire and a statistical analysis was carried out by using the Statistical Package for Social “IBM SPSS Statistics for Windows, version IBM SPSS Statistics for Windows, version XXII (IBM V.22). Result: It was observed that almost two-thirds (62.0%) of subjects belonged to age 12months in the term NBW and 28 (56.0%) in the term LBW. The mean age was 11.9 ± 0.6months in the term NBW and 12.2 ± 0.7months in the term LBW. More than half (58.0%) of subjects were male in the term NBW and 22(44.0%) in the term LBW. The majority (88.0%) of subjects came from urban areas in the term NBW and 37(74.0%) in the term LBW. The mean gestational age was 39.1 ± 0.8 weeks in the term NBW and 37.7 ± 0.8weeks in the term LBW. The mean SBP was 86.6 ± 8.0mmHg in the term NBW and 92.4 ± 7.9mmHg in the term LBW. The mean diastolic blood pressure was 49.2 ± 4.3mmHg in the term NBW and 52.2 ± 4.7 mmHg in the term LBW. The mean creatinine was 0.5 ± 0.13mg/dL in the term NBW and 0.53 ± 0.12 mg/dL in the term LBW. The mean spot urine protein creatinine ratio was 0.3 ± 0.06 in the term NBW and 0.4 ± 0.07 in the term LBW. The mean glomerular filtration rate (GFR) was 72.8 ± 19.1mL/min/1.73 m2 in the term NBW and 66.4 ± 16.7 mL/min/1.73 m2 in the term LBW. The mean kidney length was 5.5 ± 0.3 in the term NBW and 5.3 ± 0.3 in the term LBW. The mean breadth was 4.3± 0.2 in the term NBW and 4.0 ± 0.1 in the term LBW. The mean thickness was 2.2 ± 0.2 in the term NBW and 2.0 ± 0.3in the term LBW. The mean kidney volume was 27.4 ± 3.7 cm3 in the term NBW and 22.9 ± 3.6 cm3 in the term LBW. In the male group, the mean kidney volume was 28.1 ± 3.9 cm3 in the term NBW and 22.4 ± 2.7 cm3 in the term LBW. In the female group, the mean kidney volume was 26.5 ± 3.3 cm3 in the term NBW and 23.4 ± 4.2 cm3 in the term LBW. In the male group, the mean estimated GFR was 75.2 ± 17.9 mL/min/1.73 m2 in the term NBW and 67.1 ± 15.6mL/min/1.73 m2 in the term LBW. In the female group, the mean estimated GFR was 69.3 ± 20.6 mL/min/1.73 m2 in the term NBW and 65.8 ± 17.8 mL/min/1.73 m2 in the term LBW. Conclusion: This study demonstrates that blood pressure and spot urine protein creatinine ratio were significantly elevated in LBW babies. Kidney length (D1), breadth (D2), and thickness (D3) were smaller in LBW babies. LBW can potentially lead to adverse effects on kidney size and function in children.Low birth weightnormal birth weightrenal volume.Journal ArticleIndiaDepartment of Pediatric Infectious Diseases and Community Pediatrics, Bangladesh Shishu Hospital and Institute, Dhaka, BangladeshDepartment of Pediatric Infectious Diseases and Community Pediatrics, Bangladesh Shishu Hospital and Institute, Dhaka, BangladeshDepartment of Pediatric Infectious Diseases and Community Pediatrics, Bangladesh Shishu Hospital and Institute, Dhaka, BangladeshDepartment of Pediatric Infectious Diseases and Community Pediatrics, Bangladesh Shishu Hospital and Institute, Dhaka, Bangladesh