Sihota, RAgarwal, H CRajashekar, Y L1996-06-012009-05-291996-06-012009-05-291996-06-01Sihota R, Agarwal HC, Rajashekar YL. A comparative evaluation of pilocarpine 1% and clonidine 0.125% versus timolol 0.5%. Indian Journal of Ophthalmology. 1996 Jun; 44(2): 87-9http://imsear.searo.who.int/handle/123456789/69828All the presently available antiglaucoma medications have either local or systemic adverse effects. Combinations of drugs are being used not only to increase the effectivity and compliance but also to decrease the incidence and magnitude of side effects. The single dose response of open angle glaucoma eyes to pilocarpine 1%, clonidine 0.125%, a combination of pilocarpine 1% and clonidine 0.125%, and timolol 0.5% was studied in a double blind, masked, cross over study. Over a period of twelve hours the effectivity of the combination of pilocarpine 1% and clonidine 0.125% was significantly more than that of either drug alone and was found to be similar to that of timolol 0.5%. No local or systemic adverse effects were seen.engAdministration, TopicalAdrenergic alpha-Agonists --administration & dosageAdrenergic beta-Antagonists --administration & dosageAdultBlood Pressure --drug effectsClonidine --administration & dosageCross-Over StudiesDouble-Blind MethodDrug Therapy, CombinationFemaleGlaucoma, Open-Angle --drug therapyHumansIntraocular Pressure --drug effectsMaleMiddle AgedMuscarinic Agonists --administration & dosageOphthalmic SolutionsPilocarpine --administration & dosageTimolol --administration & dosageClinical Trial