Singh, MDeorari, A KAggarwal, RPaul, V K1995-12-012009-05-271995-12-012009-05-271995-12-01Singh M, Deorari AK, Aggarwal R, Paul VK. Assisted ventilation for hyaline membrane disease. Indian Pediatrics. 1995 Dec; 32(12): 1267-74http://imsear.searo.who.int/handle/123456789/8037OBJECTIVES: To study the outcome and complications of assisted ventilation in neonates with hyaline membrane disease (HMD). DESIGN: Retrospective study. SETTING: Hospital based. SUBJECTS: Seventy five premature neonates with HMD needing assisted ventilation born over a period of five years. MAIN OUTCOME MEASURES: Survival rate among those ventilated and complications of assisted ventilation. RESULTS: Survival on assisted ventilation improved from initial 22.2% in 1989 to 77.8% in 1993. Of 19 babies weighing between 750-1000 g, 8(42.1%) survived. Twelve of 27 babies (44.4%) with a gestation of less than 28 weeks survived. Survival rates in babies with gestation of more than 33 weeks was 94%. Intraventricular hemorrhage was the leading cause of death in 52% babies. Nosocomial infections were common and occurred in 50.6% of infants on ventilation and accounted for one-third of deaths. Pneumothorax occurred in one-fifth of babies and was responsible for 3 deaths. Pulmonary interstitial emphysems was observed in 6 babies. Six babies developed bronchopulmonary dysplasia while 7 had retinopathy of prematurity. CONCLUSIONS: Outcome of neonates needing assisted ventilation for HMD has shown consistent improvement over the period of study. Nosocomial infections continue to be a major complication of assisted ventilation in neonates.engCause of DeathCross Infection --etiologyHumansHyaline Membrane Disease --mortalityInfant, NewbornRespiration, Artificial --adverse effectsRetrospective StudiesSurvival AnalysisTreatment OutcomeJournal Article