Naka, IzumiOhashi, JunPatarapotikul, JintanaHananantachai, HathairadLooareesuwan, SornchaiTokunaga, Katsushi2009-05-272009-05-272003-09-24Naka I, Ohashi J, Patarapotikul J, Hananantachai H, Looareesuwan S, Tokunaga K. Genetic variants of beta-globin gene in Thai malaria patients. The Southeast Asian Journal of Tropical Medicine and Public Health. 2003 ; 34 Suppl 2(): 29-31http://imsear.searo.who.int/handle/123456789/30636The Southeast Asian Journal of Tropical Medicine and Public Health.Hemoglobin E (E26K variant of beta-globin gene) causing hemoglobinopathy is commonly observed in parts of Thailand, regardless of the hematologic disadvantage of the homozygotes. In order to detect further variants of the beta-globin gene, we performed variation screening for exon 1 of the beta-globin gene in 64 adult patients with P. falciparum malaria, living in northwest Thailand. We identified E26K and two novel variants, 59C>T and IVS+1G>T. IVS+1G>T lies on the splice donor site, and a substitution of A for G at the same site (IVS+1G>A) is known to be linked to beta-thalassemia. Thus, the biological significance of IVS+1G>T and its association with malarial infection should be clarified in future studies.engAnimalsBeta-Globulins --geneticsGenetic VariationHemoglobin E --geneticsHumansMalaria, Falciparum --geneticsPolymerase Chain ReactionThailand --epidemiologyJournal Article