Lahoti, N GNatarajan, AKaruna, RD'Souza, R E2000-10-042009-06-022000-10-042009-06-022000-10-04Lahoti NG, Natarajan A, Karuna R, D'Souza RE. Cutaneous histiocytic lesions: a clinical dilemma. Journal of Postgraduate Medicine. 2000 Oct-Dec; 46(4): 275-7http://imsear.searo.who.int/handle/123456789/117309The diagnosis of malignant histiocytosis requires a high index of clinical suspicion, awareness of its atypical features and availability of various tissue samples for morphological and special studies. The case reported here highlights the diagnostic difficulties encountered in a patient diagnosed as malignant histiocytosis who presented with cutaneous lesions in multiple foci, which included the face, groin and forearm. Only after repeated biopsies and special stains, a diagnosis of malignant histiocytosis was arrived at. Chemotherapy with CHOP regimen (cyclophosphamide, doxorubicin, vincristine and prednisone) was initiated. The response to chemotherapy was good and the patient is doing well eleven months after initial diagnosis.engAntineoplastic Combined Chemotherapy Protocols --therapeutic useCyclophosphamide --therapeutic useDoxorubicin --therapeutic useFacial Neoplasms --diagnosisForearmGroinHistiocytic Sarcoma --diagnosisHumansMaleMiddle AgedPrednisone --therapeutic useSkin Neoplasms --diagnosisVincristine --therapeutic useCase Reports