Piya-Anant, ManeeSwasdimongkol, Siripong2012-05-222012-05-222012-01Piya-Anant Manee, Swasdimongkol Siripong. Outcome of intra-amniotic hypertonic saline instillation for second-trimester abortion. Siriraj Medical Journal, 2012 Jan; 64(1): 15-17.http://imsear.searo.who.int/handle/123456789/138554Objective: To evaluate the efficacy and safety of intra-amniotic hypertonic saline instillation for second trimester abortion. Methods: The pregnant women whose pregnancies were complicated by serious fetal abnormalities, trisomy 21 and thalassemia HbE disease, were admitted at Siriraj Hospital from January 1, 2009 to April 30, 2010. The patients were legally induced abortion by intra-amniotic hypertonic saline instillation. Results: A total of 42 pregnant women were retrospectively studied. The average gestational age was 22.4 ± 2.2 weeks. The average instillation-abortion time was 34.8 ± 18.2 hours. All abortuses were dead at the time of abortion. The number of complete abortions were 39 cases (92.9%). There were no serious complications in this study. Conclusion: Intra-amniotic hypertonic saline instillation for second trimester abortion should be considered as a good method in terms of efficacy and safety.enIntra amniotic hypertonic saline instillationsecond trimester abortionArticle