Deshpande, J MKamat, J RRao, V KNadkarni, S SKher, A SSalgaokar, S DRodrigues, J J1995-02-012009-05-271995-02-012009-05-271995-02-01Deshpande JM, Kamat JR, Rao VK, Nadkarni SS, Kher AS, Salgaokar SD, Rodrigues JJ. Prevalence of antibodies to polioviruses & enteroviruses excreted by healthy children in Bombay. Indian Journal of Medical Research. 1995 Feb; 101(): 50-4http://imsear.searo.who.int/handle/123456789/25436A total of 132 healthy children between the ages one month and 12 yr were surveyed to determine the prevalence of antibodies to the three poliovirus serotypes. Among infants up to six months of age, 73.2, 85.4 and 56.1 per cent had antibodies to poliovirus types 1, 2 and 3, respectively. In children of age groups 7 months to 3 yr and above 3 yr, antibody prevalence to the three poliovirus serotypes was 90.2, 86.9 and 57.4, and 83.3, 96.7 and 76.7 per cent, respectively. Immunization coverage with three doses of OPV exceeded 85 per cent in children above 7 months of age. Low seroprevalence to type 3 poliovirus in the children was conspicuous. Of the 80 faecal samples studied from these children, 24 (30%) were positive for virus. Among these isolates, 16 were poliovirus type 1 and three type 2. Intratypic differentiation revealed that 15 of the 16 poliovirus type 1 isolates were of wild origin. Two out of the three poliovirus type 2 isolates were of oral poliovaccine origin. Our data indicate that in spite of good vaccination coverage wild poliovirus type 1 circulation was endemic in Bombay and; that a large number of children were susceptible to poliovirus type 3 infections.engAntibodies, Viral --analysisChildChild, PreschoolFemaleHumansIndia --epidemiologyInfantInfant, NewbornMalePoliomyelitis --epidemiologyPoliovirus --immunologyPoliovirus Vaccine, Oral --administration & dosagePrevalenceJournal Article