Sircar, S STandon, O P1997-01-012009-06-011997-01-012009-06-011997-01-01Sircar SS, Tandon OP. Effect of aminophylline on muscle fatigue. Indian Journal of Physiology and Pharmacology. 1997 Jan; 41(1): 75-8http://imsear.searo.who.int/handle/123456789/108139The effects of two different concentrations of aminophylline, 50 microM/L and 500 microM/L on muscle fatiguability were tested using frog gastrocnemius-sciatic preparations. Two stimulation protocols, one high energy demand, and the other low energy demand were used to induce muscle fatigue. The indices of fatigue employed were (a) the decrease in peak tetanic contraction, (b) the increase in half-contraction time and (c) the increase in the contraction period in response to a high-energy-demand stimulation protocol of fatigue-induction. At the same time, it prolongs the increase in relaxation50-80 time in response to the same protocol.engAminophylline --pharmacologyAnimalsBronchodilator Agents --pharmacologyCardiotonic Agents --pharmacologyIsometric Contraction --drug effectsMuscle Fatigue --drug effectsMuscle Relaxation --drug effectsRanidaeIn Vitro