Usha,Singh, S DGupta, SShukla, H SKhanna, SSingh, R G1989-04-012009-05-291989-04-012009-05-291989-04-01Usha , Singh SD, Gupta S, Shukla HS, Khanna S, Singh RG. Clinicopathological studies of carcinoma oesophagus with special reference to changes in surrounding epithelium. Indian Journal of Pathology & Microbiology. 1989 Apr; 32(2): 125-32http://imsear.searo.who.int/handle/123456789/73735A total 17 cases of carcinoma oesophagus were studied in a period of 2 years. Ten patients (58.82%) were males and rest were females. Maximum cases (64.70%) were seen in 5th and 6th decades. Majority of the patients belonged to low socio-economic group (47.05%) followed by middle socio-economic group (41.17%). Dysphagia was present in all cases, followed by weight loss 52.94% and other symptoms. Cancer was equally distributed in middle third and lower third of the oesophagus (41.18% in each group) only in 3 cases it was in upper third of the oesophagus. Histologically 70.5% tumours were squamous cell carcinoma, 17.64% were adenocarcinoma and 11.76% were undifferentiated carcinoma. Surrounding epithelium in 17.64 per cent cases showed chronic oesophagitis, 4 cases (23.52%) showed acanthosis and dysplasia, and two cases revealed carcinoma in situ. Hence findings of oesophagitis, acanthosis, dysplasia, carcinoma in situ suggest that oesophagitis and acanthosis may be considered as precancerous lesions.engAdenocarcinoma --pathologyAdultAgedCarcinoma --pathologyCarcinoma, Squamous Cell --pathologyEpithelium --pathologyEsophageal Neoplasms --pathologyEsophagus --pathologyFemaleHumansMaleMiddle AgedJournal Article