Salam, NasirRane, SanketDas, RituparnaFaulkner, MatthewGund, RupaliKandpal, UshaLewis, VirginiaMattoo, HamidPrabhu, SavitRanganathan, VidyaDurdik, JeannineGeorge, AnnaRath, SatyajitBal, Vineeta2015-01-122015-01-122013-11Salam Nasir, Rane Sanket, Das Rituparna, Faulkner Matthew, Gund Rupali, Kandpal Usha, Lewis Virginia, Mattoo Hamid, Prabhu Savit, Ranganathan Vidya, Durdik Jeannine, George Anna, Rath Satyajit, Bal Vineeta. T cell ageing: Effects of age on development, survival & function. Indian Journal of Medical Research. 2013 Nov; 138(5): 595-608.http://imsear.searo.who.int/handle/123456789/155051Age associated decline of the immune system continues to be a major health concern. All components of innate and adaptive immunity are adversely affected to lesser or greater extent by ageing resulting in an overall decline of immunocompetence. As a result in the aged population, there is increased susceptibility to infection, poor responses to vaccination, and increased incidence of autoreactivity. There is an increasing focus on the role of T cells during ageing because of their impact on the overall immune responses. A steady decline in the production of fresh naïve T cells, more restricted T cell receptor (TCR) repertoire and weak activation of T cells are some of the effects of ageing. In this review we summarize our present understanding of the effects of ageing on naïve CD4 T cells and potential approaches for therapeutic interventions to restore protective immunity in the aged population.enAdaptive immunityageinghaematopoietic stem cellsinnate immunityTCR repertoireT cellsthymic involutiontranscription factorsArticle