Chohan, I S2015-07-252015-07-251986-06Chohan I S. Effects of piretanide on plasma fibrinolytic activity, platelet aggregation and platelet factor-4 release in man. Journal of Biosciences. 1986 June; 10(2): 243-249.http://imsear.searo.who.int/handle/123456789/160634Piretanide, 4-phenoxy-3-(pyrrolidinyl)-5-sulphamoyl benzoic acid, apart from being an efficient diuretic, enhances endogenous plasma fibrinolytic activity after a single dose of 6 mg administered by oral route. After ingestion of the drug, acceleration of fibrinolytic acitivity became manifest within 1 h, reached its peak in 3 h and was associated with a fall in fibrinogen and diminished urokinase excretion. Piretanide did not cause lysis of fibrin in vitro. Primary platelet aggregation, induced by adenosine-diphosphate, was inhibited by piretanide. In in vitro experiments piretanide led to effective inhibition of adenosine-diphosphate-induced platelet aggregation with complete inhibition at 5 mM concentration. Piretanide led to a highly significant decrease of platelet factor-4 release.enPiretanidesynthetic fibrinolytic agentanti-platelet agentPF-4 releasediureticArticle