Kundu, DSen, SPaul, AChatterjee, ASarkar, PChakrabarti, I2020-09-242020-09-242019-02Kundu D, Sen S, Paul A, Chatterjee A, Sarkar P, Chakrabarti I. Diagnostic value of serum adenosine deaminase in Type 2 diabetic patients. International Journal of Medical Research & Review. 2019 Feb; 7(1): 1-72320-86862321-127Xhttp://imsear.searo.who.int/handle/123456789/205239Background: Adenosine deaminase (ADA) is suggested to modulate the bioactivity of insulin, but its clinical significance in Type 2 diabetes mellitus (DM) is not yet established. The present study was undertaken to evaluate serum ADA activity and serum uric acid levels in patients of Type 2 DM. Aim: To evaluate the serum ADA level and to correlate ADA levels with Blood Glucose, Glycated Hemoglobin (HbA1c) levels in Type-2 DM patients. Material and Method: It is a case control study. The subjects in this study were divided into 3 groups. Group I consisted of 50 normal healthy individuals who served as controls with no history of DM. Group II consisted of 50 patients of Type 2 DM both males & females in the age group of 40-65 years on oral hypoglycemic drugs with HbA1c <7%. Group III consisted of 50 patients of Type 2 DM both males & females in the age group of 40-65 years on oral hypoglycemic drugs with HbA1c >7 %. Serum levels of fasting blood sugar, HbA1c, ADA and uric acid were estimated in all the subjects. Results: FBS, HbA1c, ADA and serum uric acid levels were found to be increased in the patients of Type 2 DM as compared with controls. Conclusion: It is concluded that there is an increase in serum ADA levels with increase in HbA1c levels. Serum uric acid levels increased with moderately increasing levels of HbA1c <7% and then decreased with further increasing levels of HbA1c >7% (a bell-shaped relation).Type 2 Diabetes mellitusAdenosine deaminaseGlycated HemoglobinUric acidJournal ArticleIndiaAssociate Professor, Department of Biochemistry, Medical College Kolkata, West Bengal, IndiaAssociate Professor, Department of General Surgery, Medical College Kolkata, West Bengal, IndiaFinal Year PGT, Department of Biochemistry, Medical College Kolkata, West Bengal, IndiaFinal Year PGT, Department of Biochemistry, Medical College Kolkata, West Bengal, IndiaSecond Year PGT, Department of Biochemistry, Medical College Kolkata, West Bengal, IndiaSecond Year PGT, Department of Biochemistry, Medical College Kolkata, West Bengal, India