Khan, SMNazmin, FRay, RHachem, RWade, BBhinder, MAChaudhry, MBSyed, MKhan, AFatima, EUllah, I.2024-11-302024-11-302024-06Khan SM, Nazmin F, Ray R, Hachem R, Wade B, Bhinder MA, Chaudhry MB, Syed M, Khan A, Fatima E, Ullah I.. Direct-Acting Antivirals' Safety Profile in Patients with Advanced Liver Cirrhosis with Hepatitis C: A Systematic Review and Meta-Analysis. Journal of Advances in Medicine and Medical Research. 2024 Jun; 36(6): 266-2812456-8899https://imsear.searo.who.int/handle/123456789/237244Chronic hepatitis C with cirrhosis is treated with direct-acting antibiotics (DAAs). The aim of this study was to investigate the effect of direct-acting antibodies in the treatment of hepatitis C in cirrhosis. It also examines the proportion of drug-related problems, side effects, and mortality. The Cochrane Library and PubMed were thoroughly searched for the required literature. Fifteen articles were extracted for inclusion in this systematic review and meta-analysis. A total of 16 studies were thoroughly screened. The included studies provided a comprehensive picture of the effects of DAA therapy, spanning multiple study designs and sites Our analysis showed that good responses were observed with DAA regimens and that treatment discontinuation was low due to adverse events a stirring that. Few adverse events were reported, but all were mostly uncontrolled to prevent treatment discontinuation or death. In addition, meta-analytic studies on specific outcomes such as encephalopathy, ascites, hepatocellular carcinoma (HCC), adverse events, and death provided quantitative analysis about the safety of DAAs. Research also shows that DAAs have fewer side effects, deaths, and complications than other treatments.Hepatitis Cdirect-acting antivirals (DAAs)liver cirrhosissystematic reviewmeta-analysissafety profileadverse eventstreatment efficacychronic liver diseaseviral eradicationJournal ArticleIndiaKHSC College of Osteopathic Medicine, Wichita, USABronx Care Health System, Bronx, USABankura Sammilani Medical College, Bankura, IndiaSaint James School of Medicine, Illinois, USAAmerican University of Antigua, New York, USACMH Lahore Medical College and Institute of Dentistry, Lahore, PakistanCMH Lahore Medical College and Institute of Dentistry, Lahore, PakistanFatima Jinnah Medical University, Lahore, PakistanKarachi Medical and Dental College, Karachi, PakistanAkhtar Saeed Medical and Dental College, Lahore, PakistanKhyber Medical College, Peshawar, Pakistan.