Singhal, KhushbooPal, Arvind KumarTiwari, SunitaSingh, RenuKushwaha, Rashmi2020-09-242020-09-242019-04Singhal Khushboo, Pal Arvind Kumar, Tiwari Sunita, Singh Renu, Kushwaha Rashmi. Neutrophil Lymphocyte Ratio (NLR) as a Bio Inflammatory Marker in Pre-eclampsia. International Journal of Contemporary Medical Research . 2019 Apr; 6(4): d1-d32393-915X2454-7379http://imsear.searo.who.int/handle/123456789/202309Introduction: Pre-eclampsia, a systemic disease unique topregnancy, affects 3–14% of pregnant women. The aim ofthe present study was to evaluate Neutrophil LymphocyteRatio (NLR) as a bio inflammatory marker of pre-eclampsia(PE), a hypertensive disorder of pregnancy characterized byhypertension and proteinuria after 20 weeks of gestation.Material and Methods: This case control study was carriedout over a period of 10 months after informed consent andethical clearance. The study population included 70 pregnantwomen (35 pre-eclampsia cases and 35 normotensive pregnantsubjects as controls). 3 ml venous blood samples were obtainedfrom both the cases and controls. Complete blood count wasdone using semi-automated three part haematology analyserwhich gives the reading of cell counts, NLR was calculatedmanually.Results: The case group (subjects with pre-eclampsia) werefound to have higher neutrophil to lymphocyte ratio (NLR)than that of the control group. This difference was statisticallysignificant (p<0.001). The receiver operating curve (ROC)analysis showed significant diagnostic accuracy of NLR todiscriminate cases and controls (area under the curve [AUC]= 0.73, P < 0.001) at cutoff value of >= 4.86, 68.6% sensitivityand 80% specificity.Conclusion: Unlike many other inflammatory markers, NLRproves to be an inexpensive and readily available biomarkers,obtained from routinely done complete blood counts that maybe useful for prediction and diagnosis of pre-eclampsia.Neutrophil Lymphocyte RatioPre-EclampsiaPregnancyJournal ArticleIndiaJunior resident, Department of Physiology, King George’s Medical University, Lucknow, UP, IndiaSenior resident, King George’s Medical University, Lucknow, UP, IndiaDepartment of Physiology, King George’s Medical University, Lucknow, UP, IndiaProfessor and Head, Department of Physiology, King George’s Medical University, Lucknow, UP, IndiaProfessor, Department of Obstetrics and Gynaecology, King George’s Medical University, Lucknow, UP, IndiaProfessor, Department of Pathology, King George’s Medical University, Lucknow, UP, India