Sharma, Pankaj KumarSharma, Chandra Shekhar2024-09-242024-09-242024-09-242024-09-242023-12Sharma Pankaj Kumar, Sharma Chandra Shekhar . Synthesis, antimicrobial activity and Molecular docking study of some novel isoxazole incorporated benzimidazole derivatives . International Journal of Pharmaceutical Sciences and Drug Research . 2023 Nov; 15(6): 680-6870975–248Xhttps://imsear.searo.who.int/handle/123456789/231731A series of novel isoxazole-incorporated benzimidazole derivatives was synthesized and investigated for antimicrobial activity. The structures of all synthesized compounds were confirmed by means of elemental analysis, infrared spectroscopy (IR), proton nuclear magnetic resonance (1H-NMR), and liquid chromatography-mass spectrometry (LC-MS). All compounds were evaluated for antimicrobial activity cup plate method against Staphylococcus aureus, Bacillus anthracis, Pseudomonas aeruginosa, Escherchia coli, Candida albicans and Aspegillus niger. The 4d, 4f and 4j compounds showed significant activity against gram-positive and gram-negative bacteria. On the basis of the interaction energy criterion, compound 4f showed the best docking interactions equal to 7.0 kcal/mol.IsoxazoleBenzimidazoleAntimicrobial activitySynthesisMolecular dockingJournal ArticleIndiaDepartment of Pharmaceutical Chemistry, Bhupal Nobles’ College of Pharmacy, Bhupal Nobles’ University, Udaipur, Rajasthan, IndiaDepartment of Pharmaceutical Chemistry, Bhupal Nobles’ College of Pharmacy, Bhupal Nobles’ University, Udaipur, Rajasthan, India