Deshmukh, MadhaviPawar, PushpaJoseph, MaryPhalgune, UshaKashalkar, RajashreeDeshpande, Nirmala R2009-05-282009-05-282008-11-19Deshmukh M, Pawar P, Joseph M, Phalgune U, Kashalkar R, Deshpande NR. Efficacy of 4-methyl-7-hydroxy coumarin derivatives against vectors Aedes aegypti and Culex quinquefasciatus. Indian Journal of Experimental Biology. 2008 Nov; 46(11): 788-92http://imsear.searo.who.int/handle/123456789/597284-Methyl-7-hydroxy coumarin is considered as a lead molecule as a biopesticide. Its mono bromo and tribromo derivatives were synthesized. Two more derivatives were synthesized by acylation. Compound 1 (3,6,8-tribromo-7-hydroxy-4-methyl-chromen-2-one) was found to be the most potent against IVth instar larvae of C. quinquefasciatus and A. aegypti the LC50 being 1.49 and 2.23 ppm respectively. It showed 100% larval mortality at 25 ppm against A. aegypti and at 10 ppm against C. quinquefasciatus. Compounds 1 and 2 (3,6,8-tribromo-7-hydroxy-4-methyl-chromen-2'-oxo-2H-chromen-7-yl acetate) showed remarkable ovicidal activity. Significant reduction of 80-85% hatching of eggs of both mosquito species was observed at the highest dose of 100 ppm. The hatched larvae showed 100% mortality in the successive instars. Compounds 3 and 4 (3-bromo-7-hydroxy-4-methyl-chromen-2-one and 3-bromo-4-methyl-2'-oxo-2H-chromen-7-yl acetate) showed moderate activity against both mosquito species.engAedes --drug effectsAnimalsBiological AssayChemistry, Pharmaceutical --methodsCulex --drug effectsDrug DesignDrug Evaluation, PreclinicalHymecromone --administration & dosageInsecticide Resistance --drug effectsInsecticides --pharmacologyLarva --drug effectsMagnetic Resonance SpectroscopyModels, ChemicalMosquito ControlPesticides --chemistryJournal Article