Shao, B RYe, X YChu, Y H2009-05-272009-05-271992-03-01Shao BR, Ye XY, Chu YH. Comparison of effects of pyronaridine, amodiaquine, mefloquine and qinghaosu on rodent malaria. The Southeast Asian Journal of Tropical Medicine and Public Health. 1992 Mar; 23(1): 59-63http://imsear.searo.who.int/handle/123456789/36394The Southeast Asian Journal of Tropical Medicine and Public Health.Blood schizontocidal effect of antimalarials were compared by 4-day suppressive test with an extended observation period of 31 days. On a drug-sensitive Plasmodium berghei ANKA strain, pyronaridine (PND) exhibited the best effect, followed by amodiaquine (ADQ), mefloquine (MFQ), and qinghaosu (QHS). On a moderately chloroquine-resistant P. berghei NS line, the order of effects was the same, PND greater than ADQ greater than MFQ greater than QHS. On a highly pyronaridine-resistant P. berghei RP line, ADQ, MFQ and QHS showed cross resistance with PND.engAmodiaquine --administration & dosageAnimalsAntimalarials --administration & dosageArtemisininsDrug Administration ScheduleDrug Evaluation, PreclinicalDrug ResistanceFemaleMalaria --drug therapyMaleMefloquine --administration & dosageMiceNaphthyridines --administration & dosagePlasmodium bergheiSesquiterpenes --administration & dosageComparative Study