Rathod, G.Banka, S. S.Mishra, M.Parmar, P2025-08-132025-08-132025-05Rathod G, Banka SS, Mishra M, Parmar P. A short communication on Oncocytic Lesions of the Thyroid gland. International Archives of Integrated Medicine. 2025 May; 12(5): 9-122394-00262394-0034https://imsear.searo.who.int/handle/123456789/253312Oncocytic lesions of the thyroid, often referred to as Hurthle cell lesions or oncocytic changes, represent a subset of thyroid pathologies characterized by mitochondrial-rich, eosinophilic cytoplasm. Oncocytic lesions of the thyroid are covering a wide spectrum of lesions e.g. benign hyperplastic nodules to malignant thyroid neoplasms. It is very important to understand their biology, diagnostic challenges, and management strategies for clinicians as well as pathologists alike. The most common clinical presentation of patients with oncocytic thyroid lesions is a painless thyroid nodule which is discovered incidentally or during evaluation for goiter or any other thyroid lesion. According to the WHO 2022 Classification of Tumors of Endocrine Organs, oncocytic lesions of the thyroid are recognized as a distinct subset of follicular-derived neoplasms. The WHO emphasizes the importance of rigorous histopathological criteria to differentiate benign from malignant oncocytic lesions and the need for molecular profiling to complement histological findings. Ongoing research will help to refine management approaches, principally for malignant oncocytic lesions. It is very much needed that endocrinologists, pathologists, and treating surgeons collaborate with each other for optimizing patient outcomes. This article emphasized on unique clinical, diagnostic, therapeutic and pathological aspects of oncocytic thyroid lesionsOncocytic lesionsThyroid neoplasmWHO 2022 ClassificationHistopathological criteria.A short communication on Oncocytic Lesions of the Thyroid glandJournal ArticleIndiaAdditional ProfessorSenior Resident Pathology and Lab Medicine, AIIMS, Bibinagar, Telangana, IndiaSenior Resident Pathology and Lab Medicine, AIIMS, Bibinagar, Telangana, IndiaAdditional Professor and HOD