Bhowmick, SBose, RPal, MPal, S P2009-05-282009-05-281990-02-01Bhowmick S, Bose R, Pal M, Pal SP. Antiulcer activity of N-phthaloyl GABA--a new GABA mimetic agent. Indian Journal of Experimental Biology. 1990 Feb; 28(2): 190-2http://imsear.searo.who.int/handle/123456789/60068N-phthaloyl GABA (P. GABA) inhibited gastric ulceration induced by 3 hr restraint stress at 4 degrees C (CRS) in albino rats. Antiulcer activity of P. GABA was compared with sodium valproate and cimetidine. P. GABA, sodium valproate and cimetidine showed a dose dependent reduction of gastric ulceration. Pretreatment with GABA antagonists-bicuculline methiodide (0.5 mg/kg, im) or 3 mercaptopropionic acid (2 mg/kg, im) reversed the antiulcerogenic activity of both the drugs (P. GABA and sodium valproate). GABA antagonists as such did not induce gastric ulceration in normal rats.eng3-Mercaptopropionic Acid --pharmacologyAnimalsAnti-Ulcer AgentsBicuculline --analogs & derivativesCimetidine --therapeutic useDose-Response Relationship, DrugMaleRatsStomach Ulcer --drug therapyValproic Acid --therapeutic usegamma-Aminobutyric Acid --analogs & derivativesJournal Article