Phanichyakarn, PKraisarin, CSasisakulporn, CKittikool, J2009-05-272009-05-271992-12-01Phanichyakarn P, Kraisarin C, Sasisakulporn C, Kittikool J. A comparison of different intervals of administration of inhaled terbutaline in children with acute asthma. Asian Pacific Journal of Allergy and Immunology. 1992 Dec; 10(2): 89-94http://imsear.searo.who.int/handle/123456789/37016Published by the Allergy and Immunology Society of Thailand.Thirty asthmatic children, 5 to 14 years of age, 20 boys and 10 girls, were studied while having acute asthmatic attacks. Each group of 10 children received either a single dose of 6 puffs (1500 micrograms) or 3 doses of 2 puffs (500 micrograms) at 5-minute or 15-minute intervals of terbutaline pressurized aerosol inhaler through a 750-ml volumetric spacer. The onset of bronchodilatation was observed within 2 minutes in all. The 3 doses at 15-minute intervals gave the greatest bronchodilatation throughout the 6-hour study period in comparing with the other two regimens. Slightly insignificant increases in systolic blood pressure and heart rate were observed in all groups and there were no statistically significant differences among them. No serious side effects were observed.engAcute DiseaseAdministration, InhalationAdolescentAsthma --drug therapyBlood Pressure --drug effectsBronchi --drug effectsBronchoconstriction --drug effectsChildChild, PreschoolDrug Administration ScheduleFemaleHeart Rate --drug effectsHumansMaleRandom AllocationRespiratory Function TestsTerbutaline --administration & dosageClinical Trial