Deepalakshmi, P DParasakthy, KShanthi, SDevaraj, N S2009-05-282009-05-281994-11-01Deepalakshmi PD, Parasakthy K, Shanthi S, Devaraj NS. Effect of chloroquine on rat liver mitochondria. Indian Journal of Experimental Biology. 1994 Nov; 32(11): 797-9http://imsear.searo.who.int/handle/123456789/59612Chloroquine causes an increase in phospholipid and a decrease in cholesterol in liver mitochondria. A significant decrease in the activities of mitochondrial inner membrane enzymes such as NADH dehydrogenase, succinate dehydrogenase and cytochrome c oxidase is observed. Decrease in cytochrome contents and respiratory control ratio, shown by a decrease in state 3(+ADP) and an increase in state 4 (-ADP), implies decreased ATP synthesis following chloroquine administration. The results confirm drug-induced inhibition of mitochondrial respiration, thereby impairing availability and utilisation of energy.engAnimalsChloroquine --pharmacologyMaleMitochondria, Liver --drug effectsRatsRats, WistarJournal Article