Kumari, MSingh, HKeerthi, G D UMudigubba, M K.2023-07-142023-07-142020-12Kumari M, Singh H, Keerthi G D U, Mudigubba M K.. Neuropsychiatric manifestations in multiple sclerosis: clinical case report and review of literature. Open Journal of Psychiatry & Allied Sciences. 2020 Dec; 11(2): 127-1292394-20612394-2053http://imsear.searo.who.int/handle/123456789/218376Background: Multiple sclerosis (MS) is a neurological disability affecting young and middle-aged adults. Neuropsychiatric manifestations in the background of multiple sclerosis had been reported as a sporadic occurrence. Case description: Here, we report the case of a 57-year-old man who developed neuropsychiatric manifestations during the course of MS. Discussion: In our case, the presence of MS might be a possible reason for the neuropsychiatric manifestations. However, not many case reports have previously acknowledged wherein a patient developed neuropsychiatric symptoms secondary to multiple sclerosis. Conclusion: Hence, this case stresses the need for future studies assessing the relationship between multiple sclerosis and psychosis.PsychosisParesisDemyelination.Journal ArticleIndiaDepartment of Pharmacy Practice, Ramaiah University of Applied Sciences, Bangalore, Karnataka, IndiaDepartment of Psychiatry, Ramaiah Medical College, Bangalore, Karnataka, India