Reddy, Dugganapalli Dinesh KumarSindhusha, VeeraballiJagadeesh, Metta2020-04-092020-04-092019-11Reddy Dugganapalli Dinesh Kumar, Sindhusha Veeraballi, Jagadeesh Metta. Adult onset still’s disease: a diagnostic dilemma. International Journal of Advances in Medicine. 2019 Nov; 6(6): 1950-19522349-39252349-3933http://imsear.searo.who.int/handle/123456789/194435Adult onset still’s disease is a rare systemic inflammatory disorder of unknown aetiology, characterized by clinical triad (high spiking fever, evanescent rash and arthritis) and biological triad with lack of serological markers as a true gold standard makes diagnosis difficulty. Here is a case of 32year old male presented with high grade fever for 2 months, joint pains and swelling for 1month rash for 3 days. O/E: pallor and B/L tender, swollen ankle and knee joints, and P/A: splenomegaly. Investigations showed-Hb%. 8 gms, neutrophilic leucocytosis with thrombocytosis, ESR:72 mm/1h, CRP elevated. ASO-titre, RA factor and Anti CCP antibodies are negative. Adult onset still’s disease is a heterogenous and rare systemic inflammatory disorder of unknown aetiology with lack of serological diagnostic modalities.Adult onset still’s diseaseArthritisEvanescent rashHigh spiking feverPyrexia of unknown originJournal ArticleIndiaDepartment of Medicine, Rangaraya Medical College, Kakinada, Andhra Pradesh, IndiaDepartment of Medicine, SV Medical Vollege, Tirupati, Andhra Pradesh, India