Islam, M T2015-12-102015-12-102009-06Islam M T. Antioxidant activities of dithiol alpha-lipoic acid. Bangladesh Journal of Medical Science. 2009; 8(3): 46-51.2223-47212076-0299http://imsear.searo.who.int/handle/123456789/167804Alpha-lipoic acid, a dithiol compound derived from octanoic acid, which acts as a coenzyme for several redox reactions in almost all the tissue of the body. It retains its protective functions in both oxidized and reduced forms. Alpha-lipoic acid reduces oxidative stress by redox generation of other antioxidants such as vitamin C, E and increasing the intracellular glutathione. Exogenous alpha-lipoic acid has been shown to increase ATP production due to its role in the oxidation of pyruvate and alpha-ketoglutarate in the mitochondria. Alpha-lipoic acid administration has been shown to be effective in preventing pathology in various experimental models in which reactive oxygen species have been implicated.enAntioxidantfree radicalalpha-lipoic acidArticle