Tongia, S KTrivedi, C PMatkar, S VChouhan, R SKaushal, R1981-07-012009-06-011981-07-012009-06-011981-07-01Tongia SK, Trivedi CP, Matkar SV, Chouhan RS, Kaushal R. Neuropharmacological actions of some newly synthesized Mannich bases. Indian Journal of Physiology and Pharmacology. 1981 Jul-Sep; 25(3): 269-73http://imsear.searo.who.int/handle/123456789/106206Benzamido (alkyl) methyl pyrrolidine Mannich bases were synthetized and subjected to certain neuropharmacological studies. All the bases reduced the pentobarbitone sleeping time and rota-rod grip of rats. The Mannich bases II, III and V raised the minimal electro-shock seizure threshold of rats. The TAB-induced pyrexia was not reduced by the bases I and III in rabbits. None of the bases showed any significant analgesic activity.engAmines --pharmacologyAnimalsBody Temperature --drug effectsBrain --drug effectsMaleMannich Bases --pharmacologyPentobarbital --pharmacologyPostural Balance --drug effectsRabbitsRatsReceptors, Drug --metabolismSensory Thresholds --drug effectsSleep --drug effectsTime FactorsJournal Article