Aggarwal, VarunSeth, AnjuJain, ManjulaKrishnamurthy, SriramChandra, VarkhaAneja, Satinder2012-10-312012-10-312010-07Aggarwal Varun, Seth Anju, Jain Manjula, Krishnamurthy Sriram, Chandra Varkha, Aneja Satinder. Congenital langerhans cell histiocytosis with skin and lung involvement: Spontaneous regression. Indian Journal of Pediatrics. 2010 July; 77(7): 811-812.http://imsear.searo.who.int/handle/123456789/142639Congenital self-healing Langerhans cell histiocytosis (CSHLCH) is a rare type of Langerhans Cell Histiocytosis, presenting at birth or during the neonatal period with eruption of multiple, discrete red-brown papules or nodules that undergo spontaneous regression. Systemic signs are generally absent. We describe a 4-month-old infant presenting with reddish brown nodular cutaneous lesions since birth with a past history suggestive of pulmonary involvement. Skin biopsy showed a dermal infiltrate of pleomorphic histiocytes; which were CD1a and S-100 positive, consistent with the diagnosis of CSHLCH. Both pulmonary and cutaneous lesions showed spontaneous resolution.enHistiocytosisCongenitalPulmonarySkinHistiocytosis, Langerhans-Cell --complicationsHistiocytosis, Langerhans-Cell --congenitalHistiocytosis, Langerhans-Cell --pathologyHumansHypopigmentation --etiologyInfantMaleRemission, SpontaneousRespiration Disorders --etiologySkin Diseases --etiologySkin Diseases --pathologyArticle