Suri, MKabra, MJain, USanders, VSaxena, RShukla, ASingh, G VVerma, I C1995-04-012009-05-271995-04-012009-05-271995-04-01Suri M, Kabra M, Jain U, Sanders V, Saxena R, Shukla A, Singh GV, Verma IC. A clinical and cytogenetic study of Turner syndrome. Indian Pediatrics. 1995 Apr; 32(4): 433-42http://imsear.searo.who.int/handle/123456789/11072Forty five case of Turner syndrome diagnosed in the Genetics Clinic, between January 1986 and December 1993, were analyzed. The most commonly observed karyotype was 45, X (44.4%), followed by 45, X/46, XX mosaicism (24.4%). Less frequently demonstrated karyotypes were 45, X/46, X, i (Xq) mosaicism and 46, X, i (Xq) (13.3%). Mosaicism for chromosome was seen in 6.7% of patients. Patients with 45, X karyotype had short stature (85%), dysmorphic facies (60%), delayed appearance of secondary sexual characters (100%) and primary amennorhea (100%). Those with 45, X/46, XX mosaicism were less often dysmorphic and presented with either primary or secondary amenorrhea. Patients with 45, X karyotype were younger at diagnosis and had a significantly shorter mean adult height than those with 45, X/46, XX mosaicism. The phenotype in patients with other karyotypic abnormalities was similar to the 45, X group. Short stature and primary or secondary amenorrhea occurring together in a female strongly suggests the possibility of Turner syndrome, which should be confirmed by chromosomal analysis.engAdolescentAdultAge of OnsetChildChild, PreschoolChromosome Aberrations --diagnosisChromosome DisordersCytogenetics --methodsDiagnosis, DifferentialFemaleFollicle Stimulating Hormone --bloodHumansKaryotypingLuteinizing Hormone --bloodMalePrognosisTurner Syndrome --complicationsJournal Article