Lu, JiameiZhu, YantingFeng, WeiPan, YilinLi, ShaojunHan, DongLiu, LuXie, XinmingWang, GuizuoManxiang, Li2015-08-182015-08-182014-09Lu Jiamei, Zhu Yanting, Feng Wei, Pan Yilin, Li Shaojun, Han Dong, Liu Lu, Xie Xinming, Wang Guizuo, Li Manxiang. Platelet-derived growth factor mediates interleukin-13-induced collagen I production in mouse airway fibroblasts. Journal of Biosciences. 2014 Sep; 39 (4): 693-700.http://imsear.searo.who.int/handle/123456789/161982Interleukin-13 (IL-13) is associated with the production of collagen in airway remodelling of asthma. Yet, the molecular mechanisms underlying IL-13 induction of collagen remain unclear; the aim of this study is to address this issue. IL-13 dose- and time-dependently-induced collagen I production in primary cultured airway fibroblasts; this was accompanied with the STAT6 phosphorylation, and pre-treatment of cells with JAK inhibitor suppressed IL-13- induced collagen I production. Further study indicated that IL-13 stimulated JAK/STAT6-dependent PDGF production and subsequent ERK1/2 MAPK activation in airway fibroblasts, and the presence of either PDGF receptor blocker or MEK inhibitor partially suppressed IL-13-induced collagen I production. Taken together, our study suggests that activation of JAK/STAT6 signal pathway and subsequent PDGF generation and resultant ERK1/2 MAPK activation mediated IL-13-induced collagen I production in airway fibroblasts.enAirway fibroblastscollagen Iinterleukin-13PDGFArticle