Siddiqui, Saif R2025-05-092025-05-092024-07Siddiqui Saif R . ENIGMA OF PRECANCEROUS LESIONS IN THE ORAL CAVITY: A COMPREHENSIVE REVIEW. Era's Journal of Medical Research. 2024 Jul; 11(1): 113-1152348-98392394-5222https://imsear.searo.who.int/handle/123456789/242615Oral precancerous lesions (OPLs) serve as crucial indicators of the potential progression to oral cancer, marking a pivotal stage in the disease continuum. Despite advancements in diagnostic and therapeutic modalities, oral cancer remains a significant global health challenge, necessitating a deeper understanding of OPLs for effective prevention and treatment strategies. This review aims to provide a comprehensive analysis of OPLs, covering their epidemiology, etiology, histopathology, molecular alterations, risk assessment, clinical management approaches , and discussion of challenges and future directions . By synthesizing the latest evidence and highlighting areas for future research, this review aims to contribute to the refinement of diagnostic algorithms, risk stratification methodologies, and personalized treatment interventions, ultimately improving patient outcomes and reducing the burden of oral cancer.Oral precancerous lesionsOral cancerGlobal health challenge.Journal ArticleIndiaDepartment of Dental Dr. KNS Memorial Institute of Medical Sciences, Ayodhya Road, Barabanki, U.P., India-225001