Pandey, MonikaAwasthi, Shally2020-11-182020-11-182020-01Pandey Monika, Awasthi Shally. Role of MMP-1, MMP-8 and MMP-9 gene polymorphisms in preterm birth. Journal of Genetics. 2020 Jan; 99: 1-70022-13330973-7731http://imsear.searo.who.int/handle/123456789/215563Novel approaches to preterm births are underway building upon our prior discoveries and probing into unknown discovery pathways. The recent findings showed a high affinity of MMP-9 in serum and its polymorphisms for preterm birth. This study, which is a hospital-based case– control study, aims to investigate the association of MMP-1, MMP-8 and MMP-9 polymorphisms, and levels of MMP-9 in preterm birth. Increased level of MMP-9 was reported in cases as compared to control. The significant association of MMP-9 (-1562) CT (P = 0.001; OR = 1.44 (CI = 0.97–2.14)) and TT genotype (P = 0.05; OR = 2.6 (CI = 1.46–4.69)) were reported in preterm birth. Our findings suggest thattheMMP-9 plays an important role in contributing preterm labour and this can be used as a diagnostic tool during pregnancyinfectioninflammationmatrix metalloproteinasespolymorphismpreterm birthJournal ArticleIndiaDepartment of Pediatrics, King George’s Medical University, Lucknow 226 003, India