Gilhotra, NeerajSharma, AjaySingh, Manjeet2009-05-282009-05-282007-07-08Gilhotra N, Sharma A, Singh M. Involvement of p38 Mapkinase in attenuation of antinociceptive effect of morphine in diabetic mice. Indian Journal of Experimental Biology. 2007 Jul; 45(7): 654-6http://imsear.searo.who.int/handle/123456789/59884Experimental diabetes induced by streptozotocin (200 mg/kg, ip) markedly decreased the antinociceptive effect of morphine and significantly increased the urinary nitrite concentration. Administration of FR-167653 (a selective p38MAPKinase inhibitor) in a dose of 4 mg/kg improved the antinociceptive effect of morphine and attenuated the increase in urinary nitrite concentration in diabetic mice. It may be concluded that diabetes-induced decrease in antinociceptive effect of morphine may be due to induction of p38 MAPKinase activity.engAnalgesics --pharmacologyAnalgesics, Opioid --pharmacologyAnimalsBlood Glucose --metabolismCyclooxygenase Inhibitors --chemistryDrug DesignFemaleMaleMiceModels, StatisticalMorphine --pharmacologyNitrites --chemistryPyrazoles --pharmacologyPyridines --pharmacologyp38 Mitogen-Activated Protein Kinases --antagonists & inhibitorsJournal Article