Izhar, RaafiahAli, GufranAbidi, Syed Sibte AkbarMahtab, Mohammad2023-08-192023-08-192022-06Izhar Raafiah, Ali Gufran, Abidi Syed Sibte Akbar, Mahtab Mohammad. Simvastatin and Its Role in Anti - Inflammation and Cancer Therapy: A Review. Indian Journal of Medical Research. 2022 Jun; 8(2): 1-72454-98942454-9886http://imsear.searo.who.int/handle/123456789/2240643 - Hydroxy - 3 - methylglutaryl - coenzyme, a reductase inhibitors (statins) are widely used drugs to reduce lipid levels by inhibiting cholesterol biosynthesis. Simvastatin, a lipophilic statin is one of the most frequently prescribed statin drugs throughout th e world due to profound reductions in LDL - C with excellent tolerability, with very little risk of important adverse effects, to a lower extent. It also reduce triglycerides and increase high - density lipoprotein cholesterol levels. Beside this, studies on simvastatin have shown to exhibit numerous pleiotropic effects, has beneficial effect on endothelial function, smooth muscle cell function, haemostasis, vascular wall function, LDL oxidation, kidney diseases, inflammation and anticarcinogenic effects on ma ny types of cancer including prostate, breast hepatic and colon carcinoma. In this review, we present aStatinsSimvastatinCVDInflammationCancerJournal ArticleIndiaDepartment of Biosciences, Jamia Millia Islamia, New Delhi, India.Department of Pharmacology, J.N. Medical College & Hospital, A.M.U., Aligarh, U.P., IndiaConsultant Physician and Diabetologist, Diabetes Care Clinic, Aligarh, U.P., IndiaIstituto di Biochimica e Biologia Cellulare, Consiglio Nazionale delle Ricerche, Naples, Italy