Alshammari, DinaSaadaldin, AfraElasbali, Abdelbaset MohamedD., FawazAlshammriAlmansi, WalidAhmed, Hussain Gadelkarim2020-09-242020-09-242019-06Alshammari Dina, Saadaldin Afra, Elasbali Abdelbaset Mohamed, D. Fawaz, Alshammri, Almansi Walid, Ahmed Hussain Gadelkarim. Expression of CK19, CD56, and Galectin-3 Tumor Markers in Different Types of Thyroid Carcinoma. International Journal of Medical Research & Health Sciences. 2019 Jun; 8(6): 125-1342319-5886http://imsear.searo.who.int/handle/123456789/204956Background: Thyroid disorders represent a major problem in Saudi Arabia, particularly in the northern part of the country. The objective of the current study was to investigate the immunohistochemical expression of CK19, CD56, and Gal-3 in a series of Saudi patients with thyroid carcinoma in Northern Saudi Arabia (Hail) region. Methodology: This is a retrospective study, investigated 50 formalin-fixed paraffin wax tissue blocks with a confirmed diagnosis of thyroid carcinoma from Northern Saudi Arabia. Immunohistochemistry demonstration was for CK19, CD56, and Gal-3 markers applying Avidin-Biotin method. Results: Out of the 50 patients, 45(90%) were females and 5(10%) were males, aged 13-70 years old with a mean age of 43 years. CK19 was positively expressed in 74% of the thyroid carcinoma. Positive CD56 expression was demonstrated in 45.7%, 58.3%, and 100% of the papillary, follicular and undifferentiated thyroid carcinomas, correspondingly. Positive Galectin-3 expression was demonstrated in 71.4%, 58.3%, and 100% of the papillary, follicular and undifferentiated thyroid carcinomas, correspondingly. Conclusion: Papillary thyroid carcinoma is the most common thyroid cancer in Northern Saudi Arabia. Females represent more than 90% of the cases of the thyroid carcinoma in Northern Saudi Arabia. CK19, CD56, and Gal-3 are useful for the assessment of thyroid carcinoma.Thyroid cancerPapillary carcinomaFollicular carcinomaSaudi ArabiaCK19CD56Gal-3Journal ArticleIndiaDepartment of Clinical Laboratory Sciences, College of Applied Medical Science, University of Hail, Hail, Saudi ArabiaDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Qurayyat, Saudi ArabiaDepartment of Pathology, College of Medicine, University of Hail, Hail, Saudi Arabia