Kumari, KMathew, B CAugusti, K T1995-02-012009-05-271995-02-012009-05-271995-02-01Kumari K, Mathew BC, Augusti KT. Antidiabetic and hypolipidemic effects of S-methyl cysteine sulfoxide isolated from Allium cepa Linn. Indian Journal of Biochemistry & Biophysics. 1995 Feb; 32(1): 49-54http://imsear.searo.who.int/handle/123456789/27384S-methyl cysteine sulphoxide (SMCS), a sulphur containing amino acid isolated from onion (Allium cepa Linn) showed antidiabetic and antihyperlipidemic effects. Oral administration of SMCS daily at a dose of 200 mg/kg body weight for a period of 45 days to alloxan diabetic rats controlled significantly their blood glucose and lipids in serum and tissues and altered the activities of liver hexokinase, glucose 6-phosphatase and HMG CoA reductase towards normal. The above effects of SMCS were comparable to those of glibenclamide and insulin.engAllium --chemistryAnimalsAntilipemic Agents --pharmacologyCysteine --analogs & derivativesDiabetes Mellitus, Experimental --drug therapyHypoglycemic Agents --pharmacologyMaleRatsRats, Sprague-DawleyJournal Article