John, SSubba, PAramugam, AGupta, SKhanna, R2025-06-192025-06-192025-03John S, Subba P, Aramugam A, Gupta S, Khanna R. A serious warning: A case report on localized amyloidosis of the oral cavity. Indian Journal of Pathology & Microbiology. 2025 Mar; 68(1): 212-2150377-49290974-5130https://imsear.searo.who.int/handle/123456789/249956Amyloidosis is a relatively rare condition with an array of complex pathophysiology. Localized amyloidosis is a rare and benign condition that practically never results in any clinical repercussions in the head and neck area. Multiple soft nodules of the tongue, lip, and cheek are the most commonly described defining characteristics of localized oral amyloidosis. These nodules originate due to the proliferation of abnormally folded protein aggregates in the body’s extracellular tissue compartments, which destroy organ structure and function. Herein, we address the case of a female infant aged one with a smooth nodule in the labial mucosa who was diagnosed with primary localized amyloidosis. When a patient is diagnosed with amyloidosis of the oral mucosa, the possibility of systemic amyloidosis or an underlying plasma cell dyscrasia must be ruled out. Surgical treatment may be beneficial for eliminating any functional impairment if primary localized amyloidosis is established.Amyloidosiskappa chainslambda chainsserum amyloid p componentJournal ArticleIndiaDepartment of Oral and Maxillofacial Pathology, King George’s Medical University, Lucknow, Uttar Pradesh, India, 1 Department of Preventive and Pediatric Dentistry, King George’s Medical University, Lucknow, Uttar Pradesh, IndiaDepartment of Preventive and Pediatric Dentistry, King George’s Medical University, Lucknow, Uttar Pradesh, IndiaDepartment of Oral and Maxillofacial Pathology, King George’s Medical University, Lucknow, Uttar Pradesh, IndiaDepartment of Preventive and Pediatric Dentistry, King George’s Medical University, Lucknow, Uttar Pradesh, India