Kumar, DAhuja, VDhar, ASharma, M P2001-09-262009-05-292001-09-262009-05-292001-09-26Kumar D, Ahuja V, Dhar A, Sharma MP. Randomized trial of a quadruple-drug regimen and a triple-drug regimen for eradication of Helicobacter pylori: long-term follow-up study. Indian Journal of Gastroenterology. 2001 Sep-Oct; 20(5): 191-4http://imsear.searo.who.int/handle/123456789/63689BACKGROUND: In developing countries, H. pylori eradication rates are suboptimal. A quadruple-drug regimen may improve on the eradication rate achieved with triple-drug regimen. METHODS: 64 consecutive patients with active duodenal ulcer associated with H. pylori infection were randomized to receive either a one-week triple-drug regimen (lansoprazole, clarithromycin, secnidazole) or a one-week quadruple-drug regimen (lansoprazole, amoxycillin, colloidal bismuth subcitrate, secnidazole). H. pylori eradication and ulcer healing were assessed 4 weeks after completion of therapy. Patients were followed up at 24 weeks and 52 weeks for H. pylori recurrence. RESULTS: Both the regimens eradicated H. pylori in 75% (95% CI 0.6-0.9) of patients. The ulcer-healing rate with the triple-drug regimen was 97% (95% CI 0.91-1.0) and 91% (95% CI 0.91-1.0) with the quadruple-drug regimen. No ulcer or H. pylori recurrence occurred in patients eradicated with the triple-drug regimen, whereas 8.3% of patients eradicated with the quadruple-drug regimen had ulcer as well as H. pylori recurrence during the 52-week follow up. CONCLUSION: Triple-drug regimen achieves similar eradication rates as quadruple-drug regimen in H. pylori infection.eng2-PyridinylmethylsulfinylbenzimidazolesAdultAmoxicillin --administration & dosageAnti-Bacterial Agents --administration & dosageAntiprotozoal Agents --administration & dosageChi-Square DistributionClarithromycin --administration & dosageDrug Therapy, CombinationDuodenal Ulcer --drug therapyEndoscopy, GastrointestinalFemaleFollow-Up StudiesHelicobacter Infections --drug therapyHelicobacter pyloriHumansLongitudinal StudiesMaleMetronidazole --administration & dosageOmeprazole --administration & dosageOrganometallic Compounds --administration & dosagePenicillins --administration & dosageProspective StudiesTreatment OutcomeClinical Trial