Kumar, AKatkuri, DRPrasad, GSAhmed, JRao, KSSReddy, BS.2025-05-122025-05-122024-08Kumar A, Katkuri DR, Prasad GS, Ahmed J, Rao KSS, Reddy BS. . Exploring the Therapeutic Benefits of Saccharomyces boulardii CNCM I-745: A Potent Probiotic Solution. International Journal of Scientific Study. 2024 Aug; 12(5): 28-372321-63792321-595Xhttps://imsear.searo.who.int/handle/123456789/246968Humans and microbes have a close symbiotic relationship, particularly in the gut, where more than 1000 species contribute to its development and maturation. The gut microbiota is essential for normal physiological development, as it supports the maturation and differentiation of the gut mucosa and its immune system. As an infant’s diet evolves, the microbiota becomes more complex, resembling that of an adult by early childhood. Malnutrition can disrupt this balance, leading to dysbiosis, which is characterized by a decrease in beneficial Bifidobacteria and an increase in harmful microbes such as Escherichia coli, Fusobacterium mortiferum, and Streptococcus spp. Dysbiosis is associated with a higher risk of various gastrointestinal diseases (GIDs), including inflammatory bowel disease, irritable bowel syndrome (IBS), and necrotizing enterocolitis. Probiotics play a crucial role in maintaining a balanced gut microbiota, making probiotic-based therapy a promising approach for preventing and treating GIDs. The mechanisms of action of probiotics include competitive adhesion and exclusion of potential pathogens, stimulation of intestinal epithelial cell proliferation, enhancement of the epithelial barrier, and interactions with the enteric nervous system and immune system. Yeasts offer several advantages as probiotics. They are stable in acidic and bile environments and can adhere to human intestinal cells. Saccharomyces boulardii CNCM I 745 is particularly effective in treating multiple gastrointestinal disorders, including traveller’s diarrhea, antibiotic-associated diarrhea (AAD), Clostridium difficile-associated syndrome, IBS, and Crohn’s disease. In addition, S. boulardii can survive the competitive environment of the intestinal tract and is naturally resistant to antibiotics and proteolysis, enhancing its effectiveness as a probiotic.Acute diarrheaDysbiosisGut microbiotaProbioticSaccharomyces boulardiiJournal ArticleIndiaDepartment of Pediatrician, Jaya Bhushan Hospital Pvt Ltd, Hyderabad, Telangana, IndiaDepartment of Paediatrician, Vatsalya Hospital, Jammikunta, Telangana, IndiaDepartment of Paediatrician, Sai Prasad Children’s Hospital, Nizamabad, Telangana, IndiaDepartment of Paediatrician, Niloufer Child Care Hospital, Nizamabad, Telangana, IndiaDepartment of Paediatrician, Sai Ayush Children’s Hospital, Nizamabad, Telangana, IndiaDepartment of Paediatrician, Sunitha Children’s Hospital, Hyderabad, Telangana, India