Kumar, NaveenKela, Anil Kumar2009-05-282009-05-282004-09-07Kumar N, Kela AK. Ondansetron amelioration of scopolamine induced cognitive deficits in three-panel runway apparatus in rats. Indian Journal of Experimental Biology. 2004 Sep; 42(9): 919-21http://imsear.searo.who.int/handle/123456789/57863Effect of ondansetron (5-HT3-receptor antagonist) was studied on the working memory deficits induced by scopolamine, a muscarinic receptor antagonist in rats using a three-panel runway apparatus. Varying doses of scopolamine (0.1-0.56mg/kg, ip) were administered alone or in combination with ondansetron (0.01-1.0 mg/kg, ip) and memory errors and latency period of the session were recorded on a three-panel runway apparatus. Treatment with scopolamine (0.56 mg/kg) produced working memory deficits in rats. Treatment with ondansetron (1.0 mg/kg) significantly reduced the scopolamine-induced working memory deficits.engAnimalsMaleMemory --drug effectsMemory Disorders --chemically inducedMuscarinic Antagonists --toxicityOndansetron --therapeutic useRatsRats, WistarScopolamine --toxicitySerotonin Antagonists --therapeutic useJournal Article