Pongpitak MikkataDenpong PatanasethanontSupon Limwattananon2011-02-202011-02-202010-03-142010-03-14Isan Journal of Pharmaceutical Sciences - วารสารเภสัชศาสตร์อีสาน; Volume 5 No.3 September-December 2009; 202-210http://imsear.searo.who.int/handle/123456789/130711The objective of this retrospective study was to determine the progression and outcomes of chronic kidney disease (CKD). Participants were patients who had serum creatinine (SCr) measurement in two district hospitals of Amnat Charoen province between 1 January 2003 and 31 December 2007. Based on definitions of the Kidney Disease Outcome Quality Initiative guideline, patients who had glomerular filtration rate (GFR) less than 60 ml/min/1.73 m² in two separate SCr measurements for at least 3 months were included. GFR was estimated using the abbreviated Modification of Diet in Renal Disease study equation. Descriptive statistics and Kaplan-Meier plots were used for analysis. At baseline, mean age was 61.5±11.3 years and 68.6% were female. At the end of a four-year follow up, 143 of 749 (19.1%) CKD stage 3 patients developed stage 4, 56 of 162 (34.6%) stage 4 patients developed stage 5, and 63 of 103 (61.2%) stage 5 patients died. Among the 103 stage 5 patients, 83 patients (80.6%) were hospitalized 4.7 times for 3.5 days, on average. For stage 4 or 5 patients, 2.3% of all prescriptions were unadjusted dosage regimens based on renal function. In conclusion, disease progression was still rapid in this study population leading to high rates of death and hospitalization. Further implementations on intervention aiming to slow the progression of patients with CKD in district hospitals should be conducted.en-USIsan Journal of Pharmaceutical Sciences - วารสารเภสัชศาสตร์อีสานOriginal Articles