T, Muhsina FathimaSaha, AbhijeetChopra, SanyaRaj, AjayBhatt, Dheeraj DeoYadav, Menka2023-08-252023-08-252023-06T Muhsina Fathima, Saha Abhijeet, Chopra Sanya, Raj Ajay, Bhatt Dheeraj Deo, Yadav Menka. Factors Associated With Hypertension and Cardiovascular Parameters in Children With Infrequently Relapsing Nephrotic Syndrome. Indian Pediatrics. 2023 Jun; 60(6): 475-4800079-60610974-7559http://imsear.searo.who.int/handle/123456789/225431Objective: To assess the prevalence of hypertension in children with infrequently relapsing nephrotic syndrome (IRNS) and its association with dyslipidemia, and end organ damage including left ventricular hypertrophy (LVH), at relapse and after steroid induced remission. Methods: Prospective observational study conducted in 83 children aged 1-12 years with IRNS, presenting in relapse. Blood pressure, fundus examination, blood and urine investigations were done at relapse and then at 4 weeks of therapy. Echocardiography at 4 weeks was performed for assessment of LVH and relative wall thickness (RWT) for concentric geo-metry (CG). Results: 27 patients (32.5%) developed hypertension, out of which 21 patients (25.3%) had stage I hypertension. Hypertension in first episode (63.0%, P<0.01) and in previous relapses (87.5%, P<0.001) was significantly associated with hypertension in the current episode. 12 patients had a positive family history of hypertension, of which 8 (66.7%) were classified under the hypertensive group (P=0.016). Concentric geometry (CG) was found in 28% of hypertensive and 5.5% of non-hypertensive children (P=0.011). On regres-sion analysis, a lower Up:Uc at the time of relapse was found to have a protective role for development of hypertension. Conclusion: One third children with IRNS had hypertension at relapse and a high proportion of hypertensive patients had CG pattern on echocardiography.Blood pressureConcentric geometryEchocardiographyEnd-organ damage.Journal ArticleIndiaDivision of Pediatric Nephrology, Department of Pediatrics, Lady Hardinge Medical College and Kalawati Saran Children’s Hospital, New DelhiDepartment of Cardiology, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr Ram Manohar Lohia (Dr RML) Hospital, New DelhiDivision of Pediatric Cardiology, Department of Pediatrics, ABVIMS and Dr RML Hospital, New Delhi.