Chogle, ANagral, ASoni, AAgale, SJamadar, Z2000-04-172009-05-292000-04-172009-05-292000-04-17Chogle A, Nagral A, Soni A, Agale S, Jamadar Z. Dapsone hypersensitivity syndrome with coexisting acute hepatitis E. Indian Journal of Gastroenterology. 2000 Apr-Jun; 19(2): 85-6http://imsear.searo.who.int/handle/123456789/65806A 14-year-old girl presented with fever, generalized lymphadenopathy, skin rash and hepatitis after starting dapsone. All abnormalities reversed with institution of prednisolone therapy after discontinuation of dapsone. The hepatic involvement was of hepatocellular type; it was associated with IgM anti-HEV antibodies, suggesting coexisting acute hepatitis E. We believe a causal link between the hepatotrophic viruses and dapsone hypersensitivity syndrome could exist.engAcute DiseaseAdolescentAnti-Inflammatory Agents --therapeutic useDapsone --adverse effectsDrug Hypersensitivity --etiologyFemaleHepatitis E --complicationsHumansLeprostatic Agents --adverse effectsLeprosy --complicationsPrednisolone --therapeutic useSyndromeCase Reports