Chowdhary, S KBhasin, D KPanigrahi, DMalik, A KKataria, R NBehra, ARoy, PSingh, K1998-01-262009-06-041998-01-262009-06-041998-01-26Chowdhary SK, Bhasin DK, Panigrahi D, Malik AK, Kataria RN, Behra A, Roy P, Singh K. Helicobacter pylori infection in patients with perforated duodenal ulcer. Tropical Gastroenterology. 1998 Jan-Mar; 19(1): 19-21http://imsear.searo.who.int/handle/123456789/124135AIM: Perforation is the commonest complication of duodenal ulcer. Helicobacter pylori is found in 95% patients with duodenal ulcer. However, there is paucity of reports on prevalence of H. pylori infection in patients with duodenal ulcer perforation. We, therefore compared the incidence of H. pylori infection in patients with duodenal ulcer perforation with the incidence in patients having complicated duodenal ulcers and non-ulcer dyspepsia. PATIENTS AND METHODS: The study was conducted on 45 patients (complicated duodenal ulcer 15, duodenal ulcer perforation 15, non-ulcer dyspepsia 15). Per-operative punch antral biopsies were taken in patients with duodenal ulcer perforation whereas endoscopic punch biopsies of antrum were taken in patients with non-ulcer dyspepsia. The criteria for H. pylori positivity was i) growth of H. pylori on culture, ii) combination of rapid urease test (RUT) and Giemsa staining, combination of RUT and Gram stain being positive for H. pylori. RESULTS: While 9 of 15 cases with complicated duodenal ulcer, 7 of 15 cases with non-ulcer dyspepsia were positive for H. pylori, none of the patients with duodenal ulcer perforation tested positive for H. pylori (p < 0.000). All patients with perforated duodenal ulcer had histological gastritis (H. pylori -ve). Fourteen of 15 patients (9 H. pylori +ve, 5 H. pylori -ve) with complicated duodenal ulcer and 9 of 15 patients (7 H. pylori +ve) with non-ulcer dyspepsia had histological gastritis. CONCLUSION: Patients with duodenal ulcer perforation do not have H. pylori infection. H. pylori negative patients of duodenal ulcer may have more predilection for perforation.engAdolescentAdultAgedAged, 80 and overChildChronic DiseaseDuodenal Ulcer --complicationsFemaleHelicobacter Infections --complicationsHelicobacter pyloriHumansMalePeptic Ulcer Perforation --complicationsJournal Article