Esan, W. S.Akintayo, C. O.Sanya, O.Oluwaseun, O. A.Olubayo, G.Adelekan, A. L.2023-07-142023-07-142023-02Esan W. S., Akintayo C. O., Sanya O., Oluwaseun O. A., Olubayo G., Adelekan A. L.. Induction and Treatment of Polycystic Ovary Syndrome with Plant Extract in Rats: A Systematic Review. European Journal of Medicinal Plants. 2023 Feb; 34(2): 34-482231-0894http://imsear.searo.who.int/handle/123456789/219533Aims: To review the induction and treatment of polycystic ovarian syndrome (PCOS) with plant extract in rats in light of the rising incidence of the condition, its accompanying physical and mental issues, and the role that sex hormone alterations play in its development. Methodology: An extensive literature search was carried out using relevant publications, which were published between 2012 and 2022 and indexed in Google Scholar, PubMed, Elsevier, Scientific Information Database, and Science Direct were investigated. Results: This review shows that the majority of research examined the levels of sex hormones in the serum, the induction of PCOS, and the treatment of animal models. The review also found that 43.75% of the studies induced PCOS with Letrozole, 31.25% with estradiol valerate, 6.25% with Testosterone Enanthate (TE), and 6.25% of the studies induced PCOS with Testosterone Propionate (TP). Conclusion: This study showed that Letrozole, Estradiol valerate, Dhea, Testosterone Enanthate, and Testosterone Propionate effectively induce PCOS in rats. Also, `plant extracts are effective in treating PCOS. More research into the mechanisms of action for plant extracts is required to complete our understanding of the reproductive endocrinological effects of plant extract treatment for PCOS.Endocrinological effectsplant extract treatmentpolycystic ovarian syndromeJournal ArticleIndiaDepartmentof Physiology, Afe Babalola University, Ado-Ekiti, NigeriaBiomedicinal Research Centre, Forestry Research Institute, NigeriaDepartment of Public Health and Biological Sciences, Blue Gate Research institute, Ibadan, Nigeria.